The science of change
The health benefits of healthy food choices and exercise are plentiful ... but how these changes occur in the body ... and especially how they help improve our health? There are several years Dean Ornish was involved in an interesting study on patients with prostate cancer. A study by Ornish published in Proceedings of the National Academy of Sciences of the United States of America showed changes in gene expression in the prostate in men undergoing intensive nutrition and lifestyle intervention that promote the prevention of prostate cancer. Analysis of global gene expression detected 48 up-regulated and regulated 453 transcripts down after the intervention. Ornish's studies have demonstrated changes expressed by improving the status of those involved in the intensive nutrition and lifestyle intervention by genes that reduce inflammation and blood pressure, and genes who supported the telomerase activity (related to the longevity of cells and slow the aging process).
food selection has been shown to modify gene expression in a manner such that there is a clear indication of some foods will upregulate genes that prevent certain diseases and down regulate genes that favor certain diseases. Ornish's studies have shown lifestyle changes which included some food choices increased gene expression that could prevent prostate cancer.
These changes are caused by a biochemical process called methylation. Protein molecules donate methyl (3 hydrogens attached to carbon 1) which binds to specific genes or by encouraging the expression of what the controls of particular genes, or stifling his "expression.
A recent study in epigenetics of how exercise effects gene expression had subjects perform one leg on a stationary bike for 45 minutes, four times a week for three months. Muscle biopsies of the leg both exercised and unexercised taken, demonstrating that approximately 5,000 sites on genes controlling muscle cell were changes in the methylation pattern. This means that there were significant changes in muscle DNA such that certain genes have been intensified and others deleted. Absolutely fascinating ... genes that decrease inflammatory and oxidative processes, while others that increase oxygen consumption and reduce the increased inflammation expression!
Surprisingly, our genes respond to biochemical signals from the types of food we eat and the exercise we are involved, and in the process facilitate the regulation of genes that could prevent the disease and downregulate genes that favor the disease. So the next time you take a bite of broccoli or go out for a brisk walk, know that you change your expression of genes promoting the prevention of certain diseases and ultimately promote your health.
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Jeff Gilliam, PT, PhD, OCS
Jeff Gilliam PT PhD: is a specialist in weight loss, who studied in detail in the areas of the health behaviors, exercise physiology and nutritional biochemistry at the University of Florida. Jeff taught a course at the University of Florida called "Search Applications to obesity and weight loss." He also taught for UF DPT program to promote health and well-being "and" Evidence Based Practice III '. His doctoral research was in the area of effective behavioral interventions for obesity and its associated diseases. He is the founder of choice of doctors for weight loss Loss a program of life / Successful weight, which can be found in more than 40 clinics in the US Southeast. He is currently clinical director of ReQuest Physical Therapy (Gainesville, Florida) and integrates the loss of life program / weight in physical therapy for his patients to help them achieve their healthy body weight.
Jeff Gilliam is an orthopedic specialist certified by the American Board of Physical Therapy Specialties.
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